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HUMAN MUTATOR GENERAL NMSH2 AND ITS RELATIONS TO HEREDITARS, NON-POLYPOPULAR COLORICAL CONTRACTS CARRINOM
HUMAN MUTATOR GENERAL NMSH2 AND ITS RELATIONS TO HEREDITARS, NON-POLYPOPULAR COLORICAL CONTRACTS CARRINOM
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机译:人类突变体一般NMSH2及其与遗传性,非多态性颜色契约的临床关系
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摘要
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error+ (RER+) tumor cells.
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