APPLICATION OF 9-DEOXY-2', 9-alpha-METHANO-3-OXA-4, 5, 6-TRINOL-3, 7-(1', 3'-INTERPHENYLENE)-13, 14-DIHYDRO-PROSTAGLANDIN F1 FOR TREATING PERIPHERAL VASCULAR DISEASE

摘要

PPROBLEM TO BE SOLVED: To provide an improved method for treating peripheral vascular diseases by using 9-deoxy-2', 9--methano-3-oxa-4, 5, 6-trinol-3, 7-(1', 3'-interphenylene)-13, 14-dihydro-prostaglandin FSB1/SB. PSOLUTION: 9-Deoxy-2', 9--methan-3-oxa-4, 5, 6-trinol-3, 7-(1', 3'-interphenylene)-13, 14-dihydro-prostaglandin FSB1/SB(UT-15) is not decomposed during passing through the lung, has a long biological half life and strong vasodilating properties for peripheral blood vessels, is a remarkably strong platelet coagulation inhibitor and inhibits release of a vasoconstrictor. Therefore, UT-15 is very effective for peripheral artery occlusion diseases and peripheral blood vessel diseases including intermittent claudication when it is administered at 0.5g-2.5mg effective dose/day/kg body weight by a peroral, an inhalational, a hypodermically muscular, a subcutaneous, an intravenous method, or the like. PCOPYRIGHT: (C)2005,JPO&NCIPI