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RADIOSENSITIVITY-ENHANCING AGENT HAVING HISTON-DEACETYLATION ENZYME INHIBITORY ACTIVITY AND METHOD FOR IDENTIFYING EFFECTIVE OPTIMUM DOSE OF THE SAME AGENT
RADIOSENSITIVITY-ENHANCING AGENT HAVING HISTON-DEACETYLATION ENZYME INHIBITORY ACTIVITY AND METHOD FOR IDENTIFYING EFFECTIVE OPTIMUM DOSE OF THE SAME AGENT
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机译:具有希氏去乙酰化酶抑制活性的放射敏感性增强剂和确定同一剂有效最佳剂量的方法
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摘要
PROBLEM TO BE SOLVED: To improve the sensitivity of cancer cells which originally have a low sensitivity to the irradiation of a radiation by a pre-treatment with a histon deacethylation enzyme inhibitor, and thereby providing a new radiation sensitizer.;SOLUTION: The enhancement of apoptosis caused by the irradiation of the radiation by pre-treating cancer cells with the histon deacethylation enzyme acting by a different mechanism from that of conventional anti-cancer agents depending on cell division is ascertained. Thereby, the expansion of adaptation and applicability of a radiation utilizing the histon deacethylation enzyme inhibitor is improved.;COPYRIGHT: (C)2005,JPO&NCIPI
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