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Circadian control method of self-renewal and differentiation of stem cells / progenitor cells, as well as circadian control method of clock control gene expression
Circadian control method of self-renewal and differentiation of stem cells / progenitor cells, as well as circadian control method of clock control gene expression
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机译:干细胞/祖细胞自我更新和分化的昼夜节律控制方法以及时钟控制基因表达的昼夜节律控制方法
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摘要
Methods of controlling bone marrow cell development, stem cell self-renewal, differentiation and/or function, and expression of clock controlled genes having an E-box sequence in their regulatory region by providing appropriate cells having a circadian clock system and manipulating the circadian clock system under conditions effective to control bone marrow cell development, stem cell self-renewal, differentiation and/or function, as well as expression of clock controlled genes having an E-box sequence in their regulatory region. In addition, an in vitro engineered tissue is disclosed that includes a plurality of cells or cell types in intimate contact with one another to form a tissue, the cells or cell types having a circadian clock system that has been modulated to regulate growth, development and/or functions of the cells or cell types within the tissue.
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