Methods including orally administering retinoid components to a human or animal having nodulocystic acne to provide substantial reduction in nodulocystic acne in the human or animal and relatively little or substantially no reduction in sebum secretion in the human or animal relative to employing a reference retinoid agent, for example, a pan active retinoid agent, in an orally administering step using an amount of the reference retinoid agent to provide the same reduction in nodulocystic acne.
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