High speed spectral domain functional optical coherence tomography and optical doppler tomography for in vivo blood flow dynamics and tissue structure

摘要

A method for tomographic imaging comprises the steps of providing a source of at least partially coherent radiation and a frequency-swept laser source through an interferometer; phase modulating the radiation in the interferometer at a modulation frequency for elimination of DC and autocorrelation noises as well as the mirror image; detecting interference fringes of the radiation backscattered from the sample into the interferometer to obtain a spectral signal; transforming the spectral signal of the detected backscattered interference fringes to obtain a time and location dependent signal, including the Doppler shift and variance, at each pixel location in a data window; and generating a tomographic image of the fluid flow in the data window and of the structure of the scanned fluid flow sample in the data window from the time and location dependent signal. The apparatus comprises a system for tomographic imaging operating according to the above method.