首页> 外国专利> Amidoacetonitrilo derived Compounds, a process for their preparation, a process for the preparation of compounds intermediaries, a composition for Combating parasites, a procedure to combat these parasites, and the use of these derivatives for the preparation of a com

Amidoacetonitrilo derived Compounds, a process for their preparation, a process for the preparation of compounds intermediaries, a composition for Combating parasites, a procedure to combat these parasites, and the use of these derivatives for the preparation of a com

机译:酰胺基乙腈衍生的化合物,其制备方法,化合物中间体的制备方法,防治寄生虫的组合物,防治这些寄生虫的方法以及这些衍生物在制备玉米粉中的用途

摘要

1. The compounds prepared by ammonium nitroformate used to deal with endo-y outta parallel, as well as nitroformate and isodihydrazide used in hot blooded animals and plants;1. Independent substitutes selected from halogen, nitrogen, cyanogen, C1-6 tar, C1-6 halide, alcoxyl C1-6, haloxyl C1-6, alcoxyl C1-6, alquenilo c2-6, haloalkoxyl c2-6, haloalquenilo c2-6, tar c2-6, C3-6 cyclopropyl calcium oxide C3-6 groups, but not replaced once or more; 6-1, 1-1-1-1, 1-6-1-1-1, 1-1-1, 1-6-1-2-quenil c2-6-uncle Alquenil c2-6-sulfur,1. Haloalquenil c2-6-sulfur, alquenil c2-6-sulfur, haloalquenil c2-6-sulfur, hydrocarbon c1-6-amino, di-acquil c1-6-amino, tar c1-6-sulfur-amine, haloalquenil c1-6-carbonilo, halogel c1-6-carbonilo, alcox c1-6-carbonilo, c1-6-carbon, c1-6-amin, c1-1-6-bonal Not replaced or replaced once or more phenylethylamine; not replaced or replaced once or more methyl benzoate; not replaced or replaced once or more phenylhydroxymethyl ether; not replaced or replaced once or more 1-phenyl-1 Or replace once or more times;unsubstituted or substituted phenylcyanomethyl one or more times; phenyl unsubstituted or substituted one or more times, the substituents being able to be independent of each other and are selected from the group consisting of halogen, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, haloalkoxy C1-6, C1-6-thio alkyl, halo C1-6-thio alkyl, C1-6 alkyl-sulfinyl, haloC 1-6 alkyl sulfinyl, C1-6 alkyl sulfonyl and haloC 1-6 alkyl sulfonyl; phenoxy unsubstituted or substituted one or more times, the substituents being able to be independent of each other and are selected from the group consisting of halogen, nitro, cyano, C1-6 alkyl, haloalkyl C1-6, alkoxy C1-6,C1-6 haloalkoxy, C1-6-thio alkyl, C1-6-thio haloalkyl, C1-6-sulfinyl alkyl, C1-6-alkyl sulfinyl, C1-6-sulfonyl alkyl and C1-6-sulfonyl alkyl; phenylacetylenyl unsubstituted or substituted one or more times, the substituents being able to be independent of each other and are selected from the group consisting of halogen, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy , C1-6-thio alkyl, halo C1-6-thio alkyl, C1-6 alkyl sulfinyl, haloC 1-6 alkyl sulfinyl, C1-6 alkyl sulfonyl and haloC 1-6 alkyl sulfonyl; and unsubstituted or substituted pyridyloxy one or more times,the substituents may be independent of each other and are selected from the group consisting of halogen, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6-thio alkyl, C1-haloalkyl -6-thio, C 1-6 alkyl sulfinyl, C 1-6 haloalkyl sulfinyl, C 1-6 alkyl sulfonyl and halo C 1-6 alkyl sulfonyl; heteroaryl unsubstituted or substituted one or more times, the substituents being able to be independent of each other and are selected from the group consisting of halogen, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy , C2-6 alkenyloxy, C2-6 haloalkenyloxy, C1-6-thio alkyl, C1-6-thio haloalkyl, C1-6-sulfinyl alkyl,halo C1-6-sulfinyl, C2-6-thio alkenyl, halo C2-6-thio-alkenyl, C2-6-sulfinyl alkenyl, C2-6-sulfinyl haloalkenyl, C1-6-sulfonyl alkyl and C1-6-sulfonyl haloalkyl , C2-6 alkenyl sulfonyl, C2-6 haloalkenyl sulfonyl, C1-6-amino alkyl and di- C1-6 alkyl alkyl; or naphthyl or quinolyl unsubstituted or substituted one or more times, the substituents being able to be independent of each other and are selected from the group consisting of halogen, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, haloalkoxyl C1-6, C2-6 alkenyloxy, C2-6 haloalkenyloxy, C1-6-thio alkyl, C1-6-thio haloalkyl, C1-6-sulfinyl alkyl, C1-6-halofinalkyl, C2-6-thio alkenyl,C2-6-thio halo-alkenyl, C2-6-sulfinyl alkenyl, C2-6-sulfinyl haloalkenyl, C1-6-sulfonyl and haloC 1-6-sulfonyl alkyl, C2-6-alkenyl sulfonyl, C2-6-sulfonyl haloalkenyl , C2-6 haloalkenyl-sulfonyl, C1-6-amino alkyl and di- C1-6-amino alkyl; R 1 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, allyl or C 1-6 alkoxy-methyl; R2, R3, R4, R5, R6, R7 and R8 either independently of each other,1. Hydrogen, halogen, C1-6 tar, not replaced or replaced with halogen once or more; 2-6 hydrazide, not replaced or replaced with halogen once or more; 2-6 tar, not replaced or replaced with halogen once or more; 1 C1-6 halogen, which has not been replaced or replaced one or more times, or replaced one or more times, can be selected from C1-6 halogen and tar group as independent substitutes, or benzene which has not been replaced or replaced one or more times,the substituents may be independent of one another and is selected from the group consisting of halogen, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6-thio alkyl, C1 haloalkyl -6-thio, C1-6 alkyl sulfinyl, haloC 1-6 alkyl sulfinyl, C1-6 alkyl sulfonyl, haloC 1-6 alkyl sulfonyl, C 1-6 alkyl or di C 1-6 alkyl; or R2 and R3 are together C2-6 alkylene; and X is C (R3) (R4) -C (R5) (R6) or C (R7) = C (R8),A preparation procedure, an intermediate compound preparation procedure, a parasite control ingredient, a parasite control procedure, and the preparation of pharmaceutical ingredients using these derivatives. Active substances have advantages in pesticide properties, especially in the prevention and control of parasites in hot blooded animals.
机译:1,由硝基甲酸酯铵制得的化合物,用于处理内膜出口平行物;以及用于热血动植物的硝基甲酸酯和异二酰肼; 1。独立的取代基,选自卤素,氮,氰,C1-6焦油,C1-6卤化物,烷氧基C1-6,卤氧基C1-6,烷氧基C1-6,烷氧基c2-6,卤代烷氧基c2-6,卤代烷氧基c2-6,焦油c2-6,C3-6环丙基氧化钙C3-6基团,但一次或多次未被取代; 6-1,1-1-1-1,1-6-1-1-1,1-1-1,1-6-1-2-奎奴尔c2-6-叔丁基奎奴尔c2-6-硫,1 。卤代alquenil c2-6-硫,alquenil c2-6-硫,halalalnilil c2-6-硫,烃c1-6-氨基,二芳基c1-6-氨基,tar c1-6-硫胺,halalalquenil c1-6 -carbonilo,halogel c1-6-carbonilo,alcox c1-6-carbonilo,c1-6-carbon,c1-6-amin,c1-1-6-bonal未被取代或一次或多次被取代的苯乙胺;不更换或一次或多次更换苯甲酸甲酯;不更换或一次或多次更换苯基羟甲基醚;一次或多次不被取代或被取代的1-苯基-1或一次或多次被取代;未被取代或取代的苯氰甲基一次或多次;未被取代或被取代一次或多次的苯基,所述取代基可以彼此独立并且选自卤素,硝基,氰基,C 1-6烷基,C 1-6卤代烷基,C 1-6烷氧基,卤代烷氧基C 1。 -6,C 1-6-硫代烷基,卤代C 1-6-硫代烷基,C 1-6烷基亚磺酰基,卤代C 1-6烷基亚磺酰基,C 1-6烷基磺酰基和卤代C 1-6烷基磺酰基;苯氧基未被取代或被取代一次或多次,所述取代基能够彼此独立并且选自卤素,硝基,氰基,C 1-6烷基,卤代烷基C 1-6,烷氧基C 1-6,C 1-。 6个卤代烷氧基,C 1-6-硫代烷基,C 1-6-硫代卤代烷基,C 1-6-亚磺酰基烷基,C 1-6-烷基亚磺酰基,C 1-6-磺酰基烷基和C 1-6-磺酰基烷基;苯乙炔基未被取代或被取代一次或多次,所述取代基能够彼此独立并且选自卤素,硝基,氰基,C 1-6烷基,C 1-6卤代烷基,C 1-6烷氧基,C 1- 6卤代烷氧基,C 1-6-硫代烷基,卤代C 1-6-硫代烷基,C 1-6烷基亚磺酰基,卤代C 1-6烷基亚磺酰基,C 1-6烷基磺酰基和卤代C 1-6烷基磺酰基;取代基可以是彼此独立的并且选自卤素,硝基,氰基,C 1-6烷基,C 1-6卤代烷基,C 1-6烷氧基,C 1-6卤代烷氧基,C 1-6-硫代烷基,C 1-卤代烷基-6-硫代,C 1-6烷基亚磺酰基,C 1-6卤代烷基亚磺酰基,C 1-6烷基磺酰基和卤素C 1-6烷基磺酰基;杂芳基未被取代或被取代一次或多次,所述取代基能够彼此独立并且选自卤素,硝基,氰基,C 1-6烷基,C 1-6卤代烷基,C 1-6烷氧基,C 1- 6卤代烷氧基,C2-6烯基氧基,C2-6卤代烯氧基,C1-6-硫代烷基,C1-6-硫代卤代烷基,C1-6-亚磺酰基烷基,卤代C1-6-亚磺酰基,C2-6-硫代烯基,卤代C2 -6-硫代烯基,C 2-6-亚磺酰基链烯基,C 2-6-亚磺酰基卤代烯基,C 1-6-磺酰基烷基和C 1-6-磺酰基卤代烷基,C 2-6烯基磺酰基,C 2-6卤代烯基磺酰基,C 1-6 -氨基烷基和二-C 1-6烷基烷基;或萘基或喹啉基未被取代或被取代一次或多次,这些取代基可以彼此独立并且选自卤素,硝基,氰基,C 1-6烷基,C 1-6卤代烷基,C 1-6烷氧基,卤代烷氧基C 1-6,C 2-6烯氧基,C 2-6卤代烯氧基,C 1-6-硫代烷基,C 1-6-硫代卤代烷基,C 1-6-亚磺酰基烷基,C 1-6-卤代烷基,C 2-6-硫代烯基, C 2-6-硫代卤代烯基,C 2-6-亚磺酰基卤代烯基,C 2-6-亚磺酰基卤代烯基,C 1-6-磺酰基和卤代C 1-6-磺酰基烷基,C 2-6-烯基磺酰基,C 2-6-磺酰基卤代烯基,C 2-6卤代烯基-磺酰基,C 1-6-氨基烷基和二-C 1-6-氨基烷基; R 1是氢,C 1-6烷基,C 1-6卤代烷基,烯丙基或C 1-6烷氧基-甲基; R2,R3,R4,R5,R6,R7和R8彼此独立1。氢,卤素,C1-6焦油,一次或多次不被卤素取代; 2-6酰肼,一次或多次不被卤素取代; 2-6焦油,不可一次或多次被卤素取代; 1个C1-6卤素,其未被一次或多次替换或替代,或被一次或多次替换,可以选自C1-6卤素和焦油基团作为独立替代物,或未被替换或替代的苯或更多次,取代基可以彼此独立并且选自卤素,硝基,氰基,C 1-6烷基,C 1-6卤代烷基,C 1-6烷氧基,C 1-6卤代烷氧基,C 1-6-硫代烷基,C 1卤代烷基-6-硫代,C 1-6烷基亚磺酰基,卤代C 1-6烷基亚磺酰基,C 1-6烷基磺酰基,卤代C 1-6烷基磺酰基,C 1-6烷基或二C 1-6烷基; R 2和R 3一起为C 2-6亚烷基;或X为C(R3)(R4)-C(R5)(R6)或C(R7)= C(R8),制备步骤,中间体化合物制备步骤,寄生虫控制成分,寄生虫控制程序以及使用这些衍生物制备药物成分的方法。活性物质在农药特性方面具有优势,特别是在热血动物中的寄生虫的预防和控制方面。

著录项

  • 公开/公告号AR037746A1

    专利类型

  • 公开/公告日2004-12-01

    原文格式PDF

  • 申请/专利权人 NOVARTIS AG;

    申请/专利号AR2002P104691

  • 发明设计人

    申请日2002-12-04

  • 分类号C07C225/29;A61K31/277;A61P33/00;

  • 国家 AR

  • 入库时间 2022-08-21 22:18:53

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号