Method for increasing specific deletion mediated by the endogenous immune response of the population of pathogenic cells in a host animal immunized previously, Composition and combination comprising an Auxiliary and A hapten Carrier conjugate Th1 - used in the same.

摘要

A method of eliminating pathological cells in host The basis of this method is to improve the understanding of the host immune system, and to deal with the number of pathogenic cells by improving the disease resistance of the pathogenic cells, so as to strengthen the elimination of the endogenous immune response of the population of pathogenic cells. According to this method, immunoconjugation or hapteno conjugation is managed to the host to bind to the surface of tumor cells or pathological organisms, while the conjugation uses immuno or hapteno to label the cells of the target cell group,As a result, people with labeled cells are immunized. The presence or production of antibodies in the host body combines with immunogens or hafteno, leading to endogenous immune response. In the case of alternation, immune cells or hapteno can be directly recognized in the host. The improvement of this method includes the use of an assistant for Th1 separation to enhance the response to immunogen / hapteno. This method includes the use of an immune pair or a pair hafteno symbiont, characterized by ligation that specifically binds to a live pathogenic cell population,However, the binding of immunogen / hapteno can be recognized by antibodies or directly by host immune cells. Hapteno was selected from the tin fluoride and dinitrophenyl groups.