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A host Guest Complex, Process for their preparation, Pharmaceutical composition containing same and Use thereof for producing a medicament
A host Guest Complex, Process for their preparation, Pharmaceutical composition containing same and Use thereof for producing a medicament
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机译:宿主客体,其制备方法,包含该客体的药物组合物及其在制备药物中的用途
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摘要
A host Guest Complex, where the host is a Cyclodextrin or a mixture of Cyclodextrins, Cyclodextrin and the Guest is 5 - [4 - [2 - (n-methyl-n - (2-pyridyl) amino) ethoxy] benzyl] tiazolidin - 2.4 - dione (Compound (1)) or one of its pharmaceutically acceptable derivative or its m Ezclas.Process for the preparation of said compound and Pharmaceutical composition containing Said compound and a pharmaceutically acceptable vehicle to him. In addition, the composition may contain one or more of a combination of different Active Agent of this pharmaceutically acceptable vehicle and optionally pharmaceutically acceptable to him.Use of said Compound for preparing medicaments for the prophylaxis and / or treatment of diabetes mellitus, situations associated with Diabetes mellitus and certain complications.Claim 17: a process for the preparation of a host Guest Complex, where the host is a Cyclodextrin or a mixture of Cyclodextrins (hereinafter referred to as "also Henceforth the Cyclodextrin and the guest") is the compound (1) or one of its Pharmaceutically acceptable derivative or one of their mixtures, according to claim 1,The process is characterised in that it comprises: (a) Mixing and the Cyclodextrin Compound (1) and / or one of its pharmaceutically acceptable Derivatives with water and the process continues with the mixture until the formation of the complex is complete; or (b) To Neutralize a solution or dispersion The Cyclodextrin compound and a Derivative of (1), in an aqueous LiquidThe Neutralization is carried out by adding a suitable Neutralization Reagent, so that the host Guest Complex precipitate required; or (c) mixing a solution of compound (1), and / or one of its pharmaceutically acceptable Derivatives, in a First Solvent With a solution of a Cyclodextrin in a Second SolventIn the first and the second Solvent is chosen so that the composition of the host - Guest required precipitate Solvent mixture; or (d) mixing a solution of Cyclodextrin and the compound (1), and / or one of its pharmaceutically acceptable derivative in an aqueous LiquidWith a proper Composition of antisolvent form host Guest required to precipitate out of the Solvent mixture; or (e) Prepare a solution of the composition - Cyclodextrin and guest host mixing Compound (1), and / or one of its pharmaceutically acceptable Derivatives,In an appropriate Solvent and then separating the Solvent; or (f) generate a Cyclodextrin and a dispersion of the compound (1), and / or one of its pharmaceutically acceptable Derivatives, in a liquid and Stir until the formation of the complex is complete; and after this as To isolate the composition host - Guest required, for example by Filtration.
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