Methods of treating or preventing Alzheimer's disease in an individual is a disease evidenced by beta-amyloid deposits on or within the brain, of treating an individual who has or to prevent an individual from acquiring a disease or condition, of inhibiting the activity of beta-secretase, cleavage of an amyloid precursor protein isotype and production of beta-amyloid peptide and amyloid plaque from an animal and producing a beta-secretase complex, use of a compound and composition

摘要

"METHODS OF TREATING OR PREVENTING ALZHEIMER DAMAGE IN AN INDIVIDUAL AND A DISEASE EVIDENTIATED BY BETA-AMYLOID DEPOSITS ON OR INSIDE THE BRAIN, TO TREAT AN INDIVIDUAL WHO HAS OR TO PREVENT AN INDIVIDUAL DUE TO AN ADDITIVITY SECRETASE, CLIVING AN ISYLUS OF AMILOID PRECURSOR PROTEIN AND PRODUCTION OF PETAID BETA AMYLOID AND AMYLOID PLATE IN AN ANIMAL AND TO PRODUCE A COMPLEX OF BETA SECRETASE, USE OF A COMPOUND AND COMPOSITION ". The present invention relates to methods of treating Alzheimer's disease, and other diseases, and / or inhibiting beta-secretase enzyme, and / or inhibiting beta A peptide in a mammal by the use of known compounds of formula Wherein R ~ 1 ~, R ~ 2 ~, R ~ 3 ~, U 39, U ", V, Y, W, Q, R 39 are as defined herein.