The compound, methods for treating anxiety, depression or stress, and to treat irritable bowel su00ecndrome or Crohn's disease, pharmaceutical composition, packaging, and.Methods to demonstrate the presence or absence of CRF receptor 1 in a biological sample.To inhibit the binding of CRF to a receiver of CRF1 and to detect CRF1 receivers in a first biological sample

摘要

"Compound, methods for treating anxiety, depression or stress, and to treat irritable bowel su00ecndrome or disease of crohm, pharmaceutical composition, packaging, and.Methods to demonstrate the presence or absence of CRF receptor 1 in a biological sample.To inhibit the binding of CRF to a receiver of CRF and CRF receptor 1 to detect 1 in a first biological sample.There are provided compounds of diarilpirazina, diarilpiridina and diarilpirimidina, that act as selective modulators of the receptor CRF1.These compounds are useful in the treatment of numerous disorders of the CNS and peripheral, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders.Methods for treating such disorders and pharmaceutical compositions as well as packed are also provided.The compounds of formula I are useful as probes for the localization of CRF receptors and as standards in tests for connection of the receiver of the CRF.There are provided methods of use of the compounds in studies of location of the receiver.