Compound, pharmaceutical composition, process for preparing a pharmaceutical composition, methods for inhibiting cathepsin activity in a mammal in need thereof, for treating or preventing a disease, for treating cathepsin-dependent conditions in a mammal in need thereof, for inhibiting bone resorption, to increase bone mineral density, and to reduce the risk of fractures

摘要

"COMPOUND, PHARMACEUTICAL COMPOSITION, PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION, METHODS FOR INHIBITING CATTEPSIN ACTIVITY IN A MAMMER NEEDED, TO TREAT OR PREVENT A DISEASE, IN ORDER TO CAUSE A CONDITION, INHIBIT BONE RESORTION, TO INCREASE BONE MINERAL DENSITY, AND TO REDUCE THE RISK OF FRACTURE ". This invention relates to an unprecedented class of compounds which are cysteine protease inhibitors, including, but not limited to, cathepsin inhibitors K, L, S and B. These compounds are useful for treating diseases in which resorption inhibition is indicated. bone, such as osteoporosis.