Agents for preventing or treating neuropathy, for promoting the production or secretion of a neurotropic factor, for improving pain, neuroprotective and pharmaceutical compound, methods for preventing or treating neuropathy and for promoting the production or secretion of a neurotropic factor. improve pain to protect a nerve in a mammal and produce a compound and use of a compound

摘要

"AGENTS TO PREVENT OR TREAT NEUROPATHY, TO PROMOTE THE PRODUCTION OR SECRETION OF A NEUROTROPIC FACTOR, TO IMPROVE PAIN, NEUROPROTECTOR AND PHARMACEUTICAL, METHODS TO PREVENT OR TREAT NEUROPROOUS NEUROPROPIC, TO IMPROVE PAIN TO PROTECT A NERVE IN A MAMMER AND TO PRODUCE A COMPOUND AND USE OF A COMPOUND. " The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5 membered aromatic heterocycle containing 2 or more nitrogen atoms, which may also have substituent (s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bivalent acyclic hydrocarbon group; Z is -O-, -S-, -NR¬ 2¬, -CONR¬ 2¬- or -NR¬ 2¬CO- (R¬ 2¬ is a hydrogen atom or an optionally substituted alkyl group); Y is a bivalent acyclic hydrocarbon bond or group; R1 is an optionally substituted bivalent cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z must not be -O- or a salt of this.