4PIPERIDIN-4-YLIDEN-(3-CARBAMOYLPHENYL)METHYL BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, SPINAL INJURIES OR GASTROINTESTINAL DISORDERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

(57) The present invention relates to compounds of the formula wherein R1 is optionally substituted phenyl, pyridyl, thienyl, furyl, imidazolyl, triazolyl, pyrrolyl or thiazolyl, and salts thereof, and pharmaceutical compositions containing them, which are selective opioid dreceptors. agonists and can be used in the treatment of pain of various origins, gastrointestinal disorders, spinal cord injuries, disorders of the sympathetic nervous system and various autoimmune diseases (e.g., arthritis, skin and organ transplants, collagen diseases, various allergies). HE