METHOD FOR MODELING GRADUATED EFFECT OF COLCHICINE IN RATS OF DIFFERENT AGE AND BODY MASS FOR BLOCKING MITOTIC CYCLE IN EPITHELIAL CELLS AT STAGE OF MITOSIS

摘要

The method for modeling the graduated effect of colchicine in the rats of different age and mass of the body for blocking the mitotic cycle in the epithelial cells at the stage of mitosis consists in decreasing the dose of colchicine using for experiments the rats of the first three days of life being utmost susceptible to the toxic effect of colchicine.