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USE OF ADENOVIRAL VECTORS EXPRESSING PDGF OR VEGF FOR THE HEALING OF TISSUE DEFECTS AND FOR THE INDUCTION OF HYPERVASCULITY IN MAMMALIAN TISSUE
USE OF ADENOVIRAL VECTORS EXPRESSING PDGF OR VEGF FOR THE HEALING OF TISSUE DEFECTS AND FOR THE INDUCTION OF HYPERVASCULITY IN MAMMALIAN TISSUE
A method for repairing defects and inducing vascularization in mammalian tissue, preferably skin, involves administering to the tissue a recombinant replication defective virus, preferably adenovirus, carrying a selected growth factor gene, preferably VEGF or PDGF, under operative control of regulatory sequences which direct the expression of the growth factor(s). Also provided is a method for infecting a tissue to be transplanted with such recombinant adenoviruses prior to transplantation and, as a composition, an infected culture of human tissue to be transplanted which is infused with a selected growth factor prior to transplantation. Screening methods for the treatment of angiogenic disorders, e.g., hemangiomas and cancers, also employ an animal model on which is engrafted a full thickness human tissue infused with a growth factor.
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