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Detection and quantification of vancomycin in biological fluids.
Detection and quantification of vancomycin in biological fluids.
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机译:生物体液中万古霉素的检测和定量。
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摘要
A method for the quantification of vancomycin in a test sample, the method comprising the steps of: (a) contacting the test sample with (i) an antibody reagent comprising antibodies which are capable of specifically binding to vancomycin, the antibody produced with an immunogen of the formula: ** (formula) ** where P is an immunogenic carrier material and X is a linking moiety from 0 to 50 carbon and heteroatoms, including not more than ten heteroatoms, arranged as a straight or branched chain or cyclic, saturated or unsaturated, with the provisos that no more than two heteroatoms may be directly linked in series, the series can not contain -OO-linked radical, the radicals cíclicoscon have 6 or fewer members and that branching may occur only on carbon atoms, and (ii) a labeled reagent which is capable of displacing the binding of the antibody to the vancomycin, to form a solution reaction; and (b) measure amount of the labeled reagent in the reaction solution is or is not bound to an antibody as a function of the amount of vancomycin in the test sample, wherein said method a stable calibrator is used comprising a aqueous solution containing a stabilized vancomycin molecule with a polypeptide wherein said polypeptide does not interfere with the binding of an antibody to the vancomycin molecule.
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