PROCESS FOR THE PREPARATION OF AN INTERMEDIATE USEFUL IN THE SYNTHESIS OF IODINATED CONTRAST MEDIA

摘要

A process for the preparation of (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-(2-acetoxy-propionylamino)-2,4,6-triiodo-isophthalamide, an intermediate usefulfor thesynthesis of iopamidol, by reaction between L-5-(2-acetoxy-propionylamino)-2,4,6-triiiodo-isophthaloyl dichloride and 2-amino-1,3-propanedio in N-methylpyrrolidone andin thepresence of a base, is described.