COMPOSITIONS COMPRISING DIETHANOLAMINE SALTS OF TREPOSTINIL IN THE TREATMENT OF PULMONARY HYPERTENSION AND OTHER CARDIOVASCULAR DISEASES

摘要

This invention pertains generally to prostacyclin analogs and methods fortheir use in promoting vasodilation, inhibiting platelet aggregation andthrombusformation, stimulating thrombolysis, inhibiting cell proliferation (includingvascularremodeling), providing cytoprotection, preventing atherogenesis and inducingangiogenesis. Generally, the compounds and methods of the present inventionincreasethe oral bioavailability and circulating concentrations of treprostinil whenadministeredorally. Compounds of the present invention have formula (I).