NASAL SPRAY FORMULATION OF ADRENOCORTICOTROPIC HORMONE(ACTH) TO TREAT TERTIARY ADRENAL INSUFFICIENCY BY ADMINISTRATION THROUGH NASAL CAVITY

摘要

PURPOSE: Provided is a nasal spray formulation of adrenocorticotropic hormone(ACTH) for treating tertiary adrenal insufficiency. The hormone, ACTH is administered through the nasal cavity and recovers tertiary adrenal insufficiency. CONSTITUTION: The nasal spray formulation of adrenocorticotropic hormone(ACTH) is manufactured by dissolving 5-30 wt.% of ACTH, 0.01-0.5 wt.% of stabilizing agent and 0.01-0.3 wt.% of surfactant in 70-95 wt.% of phosphate-buffered saline(PBS).