ORAL PHARMACEUTICAL COMPOSITION COMPRISING ACECLOFENAC WHICH IS USEFUL FOR TREATMENT OF DISTAL INTERPHALANGEAL ARTHRITIS AND MISOPROSTOL WHICH REDUCES SIDE-EFFECTS CAUSED BY ACECLOFENAC AND MANUFACTURING METHOD THEREOF

摘要

PURPOSE: A oral pharmaceutical composition comprising aceclofenac and misoprostol and a manufacturing method thereof are provided, which misoprostol reduces side-effects such as stomach disorder caused by aceclofenac which is useful for treatment of distal interphalangeal arthritis. CONSTITUTION: The oral pharmaceutical composition comprises 50 to 300 mg of aceclofenac and 100 to 800 mcg of misoprostol or pharmaceutically acceptable salts or hydrates thereof, and at least one pharmaceutically acceptable diluents. A soft capsule comprises the oral pharmaceutical composition comprising aceclofenac and misoprostol, wherein a drug dissolving agent contained in the soft capsule is one or more selected from PEG, polyethylene, diethyleneglycolmonoethylether, triacetine and diethanolamine. A fast dissolving tablet comprises the oral pharmaceutical composition comprising aceclofenac and misoprostol, wherein an agent inducing fast dissolving contained in the fast dissolving tablet is one or more selected from crossforbidon, pregelatinized starch, dried corn starch, starch sodium glyconate, low substituted hydroxypropylcellulose, crosscamelos sodium.