Means for treatment of inflammatory and degenerative joint disease, implants synovial fluid method for treating inflammatory and degenerative joint diseases (Options) and a device for delivering drug to the affected areas

摘要

1. a u0434u043bu00a0 u043bu0435u0447u0435u043du0438u00a0 inflammatory and degenerative diseases of the joints, comprising an effective amount of hyaluronic acid, u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 so that it u043fu043eu043bu043du0438u0442u0435u043bu044cu043du043e contains u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442 next correlation components, mas.%.;u0433u0438u0430u043bu0443u0440u043eu043du043eu0432u0430u00a0 acid 0.05 s.;u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442 0025 - 0.500;buffer solution or;u0431u0438u0434u0438u0441u0442u0438u043bu043bu0438u0440u043eu0432u0430u043du043du0430u00a0 water the rest.;in this u0433u0438u0430u043bu0443u0440u043eu043du043eu0432u0430u00a0 acid has u043cu043eu043bu0435u043au0443u043bu00a0u0440u043du0443u044e mass more than 500'000.;2. a u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 1, so that the buffer solution has a ph between 6.5 and 7.5.;3. a u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 1, so that it further contains dimethyl sulfoxide, diclofenac u043du0430u0442u0440u0438u00a0, paraben, chlorhexidine u0431u0438u0433u043bu044eu043au043eu043du0430u0442, which serum well u0435u0442u0438u0447u0435u0441u043au0443u044e dairy, with the following components: ratio of mas.;dimethyl sulfoxide 10 - 15;diclofenac u043du0430u0442u0440u0438u00a0 0.050, 0.075;paraben 0.35 and 0.55;chlorhexidine u0431u0438u0433u043bu044eu043au043eu043du0430u0442 0.10 0.15;u043eu0442u0434u0443u0448u043au0430 00010 - 00015;serum u043au043eu0441u043cu0435u0442u0438u0447u0435u0441u043au0430u00a0 u043cu043eu043bu043eu0447u043du0430u00a0 50 - 60;in this u0438u0441u043fu043eu043bu044cu0437u0443u0435u0442u0441u00a0 2 - 3% solution u0434u0438u043au043bu043eu0444u0435u043du0430u043au0430 u043du0430u0442u0440u0438u00a0.;4. a u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 3, so that it further contains the extract of the roots of u043eu043au043eu043fu043du0438u043au0430 production of 0.15 to 0.25 mas.%.;5. the use of funds u0434u043bu00a0 u043bu0435u0447u0435u043du0438u00a0 inflammatory and degenerative diseases of the joints, including 0.50 - 1.50 mas.% hyaluronic acid with u043cu043eu043bu0435u043au0443u043bu00a0u0440u043du043eu0439 weighing more than 750 '000 and 0.25 - 0.50 mas. u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442u0430 in u0431u0443u0444u0435u0440u043du043eu043c solution with ph 6.5 - 7.5 as implant bursa fluid.;6. method u043bu0435u0447u0435u043du0438u00a0 inflammatory and degenerative diseases of the joints, including u0432u043du0443u0442u0440u0438u0441u0443u0441u0442u0430u0432u043du043eu0435 introduction drug based on hyaluronic acid, u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441 u00a0 because the substance further u0432u0432u043eu0434u00a0u0442 u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442 next correlation components, mas.%.;u0433u0438u0430u043bu0443u0440u043eu043du043eu0432u0430u00a0 acid 0.5 - 1.5;u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442 0.25 - 0.50;buffer solution the rest;in this u0433u0438u0430u043bu0443u0440u043eu043du043eu0432u0430u00a0 acid has u043cu043eu043bu0435u043au0443u043bu00a0u0440u043du0443u044e mass more than 750'000, buffer solution has a ph of 6.5 to 7.5, and u0432u043du0443u0442u0440u0438u0441u0443u0441u0442u0430u0432u043du043eu0435 introduction drug u043eu0441u0443u0449u0435u0441u0442u0432u043bu00a0u044eu0442 at least once a week for at least three weeks.;7. method u043bu0435u0447u0435u043du0438u00a0 inflammatory and degenerative diseases of the joints, including the processing of the affected area is changed on the basis of hyaluronic acid, u043eu0442u043bu0438u0447u0430 u044eu0449u0438u0439u0441u00a0 because the substance further u0432u0432u043eu0434u00a0u0442 u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442 next correlation components, mas.%.;u0433u0438u0430u043bu0443u0440u043eu043du043eu0432u0430u00a0 acid 0.05 s.;u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442 0025 - 0.500;buffer of the rest;in this u0433u0438u0430u043bu0443u0440u043eu043du043eu0432u0430u00a0 acid has u043cu043eu043bu0435u043au0443u043bu00a0u0440u043du0443u044e mass more than 500'000, buffer solution has a ph of 6.5 to 7.5, and processing the affected area u043eu0441u0443u0449u0435u0441u0442u0432u043bu00a0u044eu0442 u043eu043au043eu043bu043eu0441u0443u0441u0442u0430u0432u043du044bu043c lo the introduction of the drug u043au0430u043bu044cu043du044bu043c u043cu00a0u0433u043au0438u0435 tissue, at least u0442u0440u0435u043cu00a0 rates on u0434u0435u0441u00a0u0442u044c twelve injections in each, with at least u0434u0435u0441u00a0u0442u0438u0434u043du0435u0432u043du044bu043c interruption u043cu0435u0436u0434 from the courses.;8. method u043bu0435u0447u0435u043du0438u00a0 inflammatory and degenerative diseases of the joints, including the use of drugs on the basis of hyaluronic acid, u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 the sos taw) further u0432u0432u043eu0434u00a0u0442 u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442, dimethyl sulfoxide, diclofenac u043du0430u0442u0440u0438u00a0, paraben, chlorhexidine u0431u0438u0433u043bu044eu043au043eu043du0430u0442, which u043au043eu0441u043cu0435u0442u0438u0447u0435u0441u043au0443 serum yu dairy, with the following components: ratio of mas.;u0433u0438u0430u043bu0443u0440u043eu043du043eu0432u0430u00a0 acid 0.5 - 1.5;u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442 0.25 - 0.50;dimethyl sulfoxide 10 - 15;diclofenac u043du0430u0442u0440u0438u00a0 0.050, 0.075;paraben 0.35 and 0.55;chlorhexidine u0431u0438u0433u043bu044eu043au043eu043du0430u0442 0.10 0.15;u043eu0442u0434u0443u0448u043au0430 00010 - 00015;serum u043au043eu0441u043cu0435u0442u0438u0447u0435u0441u043au0430u00a0 u043cu043eu043bu043eu0447u043du0430u00a0 50 - 60;water u0431u0438u0434u0438u0441u0442u0438u043bu043bu0438u0440u043eu0432u0430u043du043du0430u00a0 rest;in this u0433u0438u0430u043bu0443u0440u043eu043du043eu0432u0430u00a0 acid has u043cu043eu043bu0435u043au0443u043bu00a0u0440u043du0443u044e mass more than 500'000, diclofenac u043du0430u0442u0440u0438u00a0 u0438u0441u043fu043eu043bu044cu0437u0443u0435u0442u0441u00a0 in the form of 2 - 3% solution, and the use of the drug u043eu0441u0443u0449u0435u0441u0442u0432u043bu00a0u044eu0442 by it u043du0430u043du0435u0441u0435u043du0438u00a0 on the skin over the area of u043fu043eu0440u0430u0436u0435u043du0438u00a0 2 - 3 times a day for at least two weeks.;9. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 point 9, so that the substance is further u0432u0432u043eu0434u00a0u0442 extract from roots u043eu043au043eu043fu043du0438u043au0430 production of 0.15 to 0.25 mas.%.;10. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 point 9 or 9, so that the diffusion of hyaluronic acid and u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442u0430 in area u043fu043eu0440u0430u0436u0435u043du0438u00a0 stimulate u044du043bu0435u043au0442u0440u043eu0444u043eu0440u0435u0437u043eu043c or u043bu0430u0437u0435u0440u043eu0444u043eu0440u0435u0437u043eu043c, il and ultrasound.;11.the device u0434u043bu00a0 drug delivery to the damaged condition of the vehicle, including a mechanical booster and medication is effective to u043bu0438u0447u0435u0441u0442u0432u043eu043c hyaluronic acid, u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 what medication further includes u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442, dimethyl - u0441u0443u043bu044cu0444u043eu043au0441u0438u0434, diclofenac u043du0430u0442u0440u0438u00a0, p u0430u0440u0430u0431u0435u043du044b, chlorhexidine u0431u0438u0433u043bu044eu043au043eu043du0430u0442, which serum makeup milk,next the ratio of components, the iau.%.;u0433u0438u0430u043bu0443u0440u043eu043du043eu0432u0430u00a0 acid 0.5 - 1.5;u0445u043eu043du0434u0440u043eu0438u0442u0438u043du0441u0443u043bu044cu0444u0430u0442 0.25 - 0.50;dimethyl sulfoxide 10 - 15;diclofenac u043du0430u0442u0440u0438u00a0 0.050, 0.075;paraben 0.35 and 0.55;chlorhexidine u0431u0438u0433u043bu044eu043au043eu043du0430u0442 0.10 0.15;u043eu0442u0434u0443u0448u043au0430 00010 - 00015;serum u043au043eu0441u043cu0435u0442u0438u0447u0435u0441u043au0430u00a0 u043cu043eu043bu043eu0447u043du0430u00a0 50 - 60;water u0431u0438u0434u0438u0441u0442u0438u043bu043bu0438u0440u043eu0432u0430u043du043du0430u00a0 rest;in this u0433u0438u0430u043bu0443u0440u043eu043du043eu0432u0430u00a0 acid has u043cu043eu043bu0435u043au0443u043bu00a0u0440u043du0443u044e mass more than 500'000 and diclofenac u043du0430u0442u0440u0438u00a0 u0438u0441u043fu043eu043bu044cu0437u0443u0435u0442u0441u00a0 in the form of 2 - 3% saline.;12. device for the p.11, u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 what medication additionally contains extract of the roots of u043eu043au043eu043fu043du0438u043au0430 production of 0.15 to 0.25 mas.%.;13. device for u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 p.11 or 12, so that a vehicle is in the form of a tissue.;14. device for u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 p.11 or 12, so that a mechanical booster is designed in the form of film production means, u043eu0431u0435u0437u0432u043eu0436u0435u043du043du043eu0433u043e to 5 - 15%.