MOLECULES OF ANTI-IDIOTIPIC ANTI-CEA ANTIBODIES AND THEIR APPLICATION AS ANTI-CANCER VACCINES

摘要

The present invention provides molecules, preferably designed immunoglubulins, suitable for use as an anti-idiotype vaccine to CEA positive tumours. The molecules induce both an MHC class I and MHC class II mediated immune response to the CEA bearing tumour cells for an efficient and sustained host anti-tumour response. The present invention provides modified versions of anti-idiotype anti-CEA antibodies, preferably mouse antibody 708, with improved vaccination properties. The modifications are related to the introduction of sequences tracts deriving from e.g. CEA, CD 55 antigen and CEA cancer-specific MHC epitopes into the variable regions of said antibody molecules.