首页>
外国专利>
2-AMINOALKYLTHIENO2,3-DPYRIMIDINES, METHOD FOR THEIR PREPARING, MEDICINAL AGENT AND METHOD FOR ITS PREPARING
2-AMINOALKYLTHIENO2,3-DPYRIMIDINES, METHOD FOR THEIR PREPARING, MEDICINAL AGENT AND METHOD FOR ITS PREPARING
展开▼
机译:2-氨基烷基噻吩并[2,3-D]嘧啶类及其制备方法,药物制剂及其制备方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
FIELD: organic chemistry, medicine, biochemistry, pharmacy.;SUBSTANCE: invention relates to 2-aminomethylthieno[2,3-d]pyrimidines of the general formula (I): wherein R1 and R2 in common with C-atoms with which they are bound form 5-7-membered monounsubstituted cycloalkenyl ring; R3 and R4 are similar or different and represent independently of one another (C1-C8)-alkoxy-group or halogen atom; R5 and R6 can be similar or different and represent independently of one another hydrogen atom, linear or branched (C1-C8)-alkyl group that can be substituted with one or more hydroxyl, (C1-C8)-alkoxy-group, amine, mono-(C1-C8-alkyl)-amine or di-(C1-C8-alkyl)-amine groups, or in common with nitrogen atom to which they are bound form a heterocyclic ring that comprises optionally one or more additional nitrogen atoms and substituted with one or more hydroxyl, (C1-C8)-alkoxy- or (C1-C8)-alkylol groups. Compounds elicit the inhibitory effect with respect to activity of phosphodiesterase V and can be used in treatment of cardiovascular system states and in disturbance in the potency injury. Also, invention describes a medicinal preparation based on compounds said, a method for its preparing and a method for preparing compounds.;EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds.;6 cl, 1 tbl, 16 ex
展开▼