Using single nucleotide polymorphism markers, present on human chromosome 9, for determining predisposition to precocious canitis

摘要

Use of at least one single nucleotide polymorphism (SNP) marker (A), on human chromosome 9, for diagnosing a predisposition to precocious canitis (greying of hair). (A) are the markers rs306534; rs3739902; rs575916 or rs365297. Independent claims are also included for the following: (1) process for diagnosing a predisposition to precocious canitis (CP) by determining the alleles of at least one (A); (2) kit for the new process comprising a system for determining the alleles of at least one (A) and a positive or negative control; (3) process for diagnosing a predisposition to develop CP by determining alleles of the chromosome 9 markers rs3739902, rs2583805 and rs377090, to establish the haplotype; (4) kit for method (3) comprising a system for detecting the relevant alleles; and (5) use of at least one fragment (I), containing at least 18 consecutive nucleotides the sequence of which corresponds to all or part of the region, in a non-human animal, that is homologous to the region of human chromosome 9 defined by SNP rs306534 and rs365297 for determining a predisposition to PC in the mammal.