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Ivermectin composition useful for treating skin disorders e.g. rosacea and seborrheic dermatitis is in the form of a gel-cream comprising an oil phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier
Ivermectin composition useful for treating skin disorders e.g. rosacea and seborrheic dermatitis is in the form of a gel-cream comprising an oil phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier
Pharmaceutical composition (C1) based on ivermectin in the form of a gel-cream comprises an oil phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier. The oil phase comprises oils melting below 30[deg]C and contains no solid fats melting above 30[deg]C. An independent claim is also included for producing (C1) at ambient temperature by mixing the constituents of the oil phase until homogeneous, dissolving the constituents of the aqueous phase in water until homogeneous, dispersing the emulsifier (and optional carbomer) in the aqueous phase to form a homogeneous gel, incorporating the oil phase into the gel by mechanical agitation, mixing the constituents of an active phase, dissolving ivermectin in the mixture, incorporating the mixture into the emulsion by mechanical agitation and adjusting the pH with a neutralizing agent using mechanical agitation. ACTIVITY : Dermatological; Antiseborrheic. MECHANISM OF ACTION : None given.
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