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Method for producing hypertrophic scarring animal model for identification of agents for prevention and treatment of human hypertrophic scarring
Method for producing hypertrophic scarring animal model for identification of agents for prevention and treatment of human hypertrophic scarring
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机译:增生性瘢痕形成动物模型的制备方法,用于鉴定预防和治疗人增生性瘢痕形成的药物
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摘要
The present invention relates to a method of producing a non-human animal model of hypertrophic scarring. This involves producing an incision in a non-human animal and applying mechanical strain over the incision under conditions effective to produce hypertrophic scarring, thereby producing a non-human animal model of hypertrophic scarring. The present invention also relates to a method of determining the efficacy of an agent for prevention or treatment of a disease condition. This method involves providing a non-human animal having an incision over which mechanical strain is applied under conditions effective to produce hypertrophic scarring, administering an agent to the incision, and determining whether the agent is efficacious for prevention or treatment of a disease condition. Also provided is a non-human animal model of hypertrophic scarring. This involves a non-human animal having an incision over which mechanical strain has been applied under conditions effective to produce hypertrophic scarring.
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