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Computer systems and methods that use clinical and expression quantitative trait loci to associate genes with traits
Computer systems and methods that use clinical and expression quantitative trait loci to associate genes with traits
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机译:使用临床和表达定量性状基因座将基因与性状相关联的计算机系统和方法
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摘要
A method for associating a gene G in the genome of a species with a clinical trait T exhibited by one or more organisms in a plurality of organisms of the species. An expression quantitative trait loci (eQTL) is identified for the gene G using a first quantitative trait loci (QTL) analysis. The first QTL analysis uses a plurality of expression statistics for gene G as a quantitative trait. Each expression statistic in the plurality of expression statistics represents an expression value for gene G in an organism in the plurality of organisms. A clinical quantitative trait loci (cQTL) that is linked to the clinical trait T is identified using a second QTL analysis. The second QTL analysis uses a plurality of phenotypic values as a quantitative trait. Each phenotypic value in the plurality of phenotypic values represents a phenotypic value for the clinical trait T in an organism in the plurality of organisms. When the eQTL and the cQTL colocalize to the same locus, the gene G is associated with clinical trait T.
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