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Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates
Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates
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机译:鉴定和调节参与活性氧中间体生产的因素的方法和转基因小鼠模型
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摘要
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The present invention additionally comprises cells and cell lines containing transgenes encoding for members of the NOX and Duox family of proteins. The present invention further comprises methods and compositions for evaluating regulators of abnormal cell growth and in the development of compounds that effect ROI expression.
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