pharmaceutical compositions in powder form, method for preparing an oral suspension of a drug, method for masking the bitter or other taste of a drug and oral suspension of de-quinolone

摘要

"PHARMACEUTICAL COMPOSITIONS IN THE FORM OF POWDER, METHOD FOR PREPARING ORAL SUSPENSION OF A DRUG, METHOD FOR MASKING BITTER FLAVOR OR OTHER FLAVOR SUSPENSION". The present invention relates to a drug formulation in the form of a dry powder which, when mixed with water, forms a palatable oral suspension substantially free of bitter taste, the dry powder being formed of a drug, preferably des-quinolone. which, in solution, has a bitter taste, and a pH-modifying agent which is preferably an alkaline material such as L-arginine, where mixing the dry powder in water causes the drug to have reduced solubility or precipitate in. situ forming a palatable oral suspension substantially free of bitter taste. Also provided is an oral suspension, methods for producing it and a method for masking the bitter taste of the drugs by employing one or more pH modifying agents.