methods for ameliorating a multiple sclerosis symptom in an individual, for ameliorating multiple sclerosis in a mammal individual, for modulating an il-10 deficiency, or a disorder associated with an il-10 deficiency in a mammalian individual, for treating or preventing an immune disorder in a mammal individual and to evaluate the treatment of multiple sclerosis in a mammal individual, pharmaceutical composition, and, article of manufacture

摘要

"METHODS FOR IMPROVING A MULTIPLE SCLEROSIS SYMPTOM IN AN INDIVIDUAL, TO IMPROVE MULTIPLE SCLEROSIS IN A MAMMAL INDIVIDUAL, TO MODULATE AN IL-10 DEFICIENCY, OR A DISORDER ASSOCIATED WITH A MALF DEFICIENT, OR PREVENT AN IMMUNOLOGICAL DISORDER IN A MAMMALIAN AND TO EVALUATE TREATMENT OF MULTIPLE SCLEROSIS IN A MAMMALIAN, PHARMACEUTICAL COMPOSITION, AND, MANUFACTURING ARTICLE ". Methods and compositions for modulating interleukin-21 (IL-21) / IL-21 receptor activity using IL-21 or IL-21 receptor ('IL-21R' or 'MU-1') agonists are described. . IL-21 / IL-21R agonists may be used alone or in combination with antiinflammatory agents to treat, e.g., ameliorate, symptoms associated with immune system disorders, e.g., multiple sclerosis.