pyrazole derivatives as phosphodiesterase 4 inhibitors, compound, pharmaceutical composition, method to effect inhibition of the enzyme pde4, increase cognition and / or treat psychosis in a patient, method for the treatment of a patient who has a disease involving levels decreased camp rates, method for treating a patient suffering from an allergic or inflammatory disease and method for treating a patient suffering from neurodegeneration resulting from an illness or injury

摘要

"PIRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS, COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITING PDE4 ENZYME, AND / OR TREATING PSYCHOSIS IN A PATIENT THAT HAS A PATIENT THAT HAS A PATIENT Decreased CAMP levels, method for treating a patient suffering from an allergic or inflammatory disease, and a method for treating a patient suffering from neurodegeneration resulting from a disease or injury. Selective inhibition of PDE4 is obtained by aryl and heteroaryl pyrazole compounds. The compounds exhibit greater PDE4 inhibition over compounds such as rolipram and exhibit selectivity with respect to inhibition of other classes of PDEs.