flucorcombretastatin and derivatives thereof

摘要

"FLUORCOMBRETASTATIN AND DERIVATIVES THEREOF". The present invention relates to novel combretastatin derivatives of formula (I) obtained by total synthesis. The strategy developed for each of the compounds is i) to replace hydrogen with a halogen (ie fluorine atom) in the olefin bond; ii) replacing an aromatic ring in a natural product with an amino aromatic ring. Said compounds recognize and bind to the tubulin site; They are useful for treating disease states that result from cell proliferation or are exacerbated by cell proliferation - such as anticancer and / or antiangiogenic activity in a mammal - for pharmaceutical compositions comprising such compounds.