USE OF BENZENESULFONYL (THIO) UREAS FOR PREPARING A MEDICAMENT FOR THE TREATMENT AND PROPHYLAXIS OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM, THEIR USE WITH BETA - RECEPTOR BLOCKERS, AND SOME SUCH NOVEL BENZENESULFONYL (THIO) UREAS

摘要

Substituted benzenesulfonylureas and -thioureas of formula (I), in which R1, R2, E, X, Y and Z have the meanings given in the claims, show effects on the autonomous nervous system. The invention relates to the use of the compounds of formula (I) in the treatment and prophylaxis of dysfunctions of the autonomous nervous system, in particular of vagal dysfunctions, for example in the case of cardiovascular diseases, and to their use for preparing medicaments for such treatment and prophylaxis. Furthermore, the invention relates to the use of compounds of formula (I) in combination with beta-receptor blockers and to products and pharmaceutical preparations which comprise at least one compound of formula (I) and at least one beta-receptor blocker, and to novel compounds.