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Ezetimible or its salts accepted in combination with Simvastatin (Inegy / Vytorin).
Ezetimible or its salts accepted in combination with Simvastatin (Inegy / Vytorin).
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机译:依泽替米贝或其盐与辛伐他汀(Inegy / Vytorin)合用。
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摘要
Hydroxy-substd. azetidinone derivs. of formula (I) and their salts are new. Ar1,Ar2 = aryl (opt. substd. by 1-5 gps. R4); Ar3 = aryl (opt. substd. by 1-5 gps. R5); X, Y, Z = CH2, CH(1-6C alkyl) or C(di(1-6C alkyl); R, R2 = OR6, OCOR6, OCOOR9 or OCONR6R7; R1, R3 = H, 1-6C alkyl or aryl; q, r = 0 or 1; m, n, p = 0-4, provided that i) at least one of q and r is 1, and the sum of m, n q and r is 1-6, and ii) when p is 0 and r is 1, the sum of m, q and n is 1-5; R4 = 1-6C alkyl, OR6, OCOR6, OCOR9, O(CH2)sOR6, OCONR6R7, NR6R7, NR6COR7, NR6COOR9, NR9, NR6CONR7R8, NR6CONR7R8, NR6SO2R9, COOR6, CONR6R7, COR6, SO2NR6R7, S(O)tR9, O(CH2)uCOOR6, O(CH2)uCONR6R7, lower alkylCOOR6, CH=CH-COOR6, CF3, CN, NO2 or halogen; R5 = OR6, OCOR6, O(CO)R9, O(CH2)vOR6, -O(CO)NR6R7, NR6R7, NR6COR7, NR6COOR9, NR6COOR9, NR6CONR7R8, NR6SO2R9, COOR6, CONR6R7, COR6, SO2NR6R7, S(O)tR9, -O(CH2)uCOOR6, O(CH2)uCONR6R7, lower alkylCOOR6 or -CH=CH-COOR6; s = 1-5; t = 0-2; u = 1-10; v = 1-5; R6, R7, R8 = H, 1-6C alkyl (opt.substd. with aryl) or aryl; and R9 = 1-6C alkyl (opt. substd. with aryl) or aryl.
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机译:羟基取代的。氮杂环丁酮衍生。式(I)的化合物及其盐是新的。 Ar 1,Ar 2 =芳基(优选被1-5gps.R 4取代); Ar 3 =芳基(优选被1-5gps.R 5取代); X,Y,Z = CH2,CH(1-6C烷基)或C(二(1-6C烷基); R,R2 = OR6,OCOR6,OCOOR9或OCONR6R7; R1,R3 = H,1-6C烷基或芳基; q,r = 0或1; m,n,p = 0-4,条件是i)q和r中的至少一个为1,且m,nq和r的总和为1-6,以及ii)当p为0且r为1时,m,q和n之和为1-5; R4 = 1-6C烷基,OR6,OCOR6,OCOR9,O(CH2)sOR6,OCONR6R7,NR6R7,NR6COR7,NR6COOR9,NR9,NR6CONR7R8,NR6CONR7R8,NR6SO2R9,COOR6,CONR6R2,O6,() (CH2)uCOOR6,O(CH2)uCONR6R7,低级烷基COOR6,CH = CH-COOR6,CF3,CN,NO2或卤素; R5 = OR6,OCOR6,O(CO)R9,O(CH2)vOR6,-O(CO)NR6R7,NR6R7,NR6COR7,NR6COOR9,NR6COOR9,NR6CONR7R8,NR6SO2R9,COOR6,CONR6R7,COR6,SO2R ,-O(CH 2)u COOR 6,O(CH 2)u CONR 6 R 7,低级烷基COOR 6或-CH = CH-COOR 6; s = 1-5; t = 0-2; u = 1-10; v = 1-5; R6,R7,R8 = H,1-6C烷基(被芳基取代)或芳基;和R9 = 1-6C烷基(被芳基取代)或芳基。
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