Synergistic immunostimulant composition, useful as adjuvant for vaccinating antigens, containing toll-like receptor 7 or 8 agonist and toll-like receptor 4 agonist

摘要

An immunostimulant composition (A) containing at least one toll-like receptor 7 or toll-like receptor 8 agonist (I) additionally contains a toll-like receptor 4 agonist (II). ACTIVITY : Immunostimulant; Antibacterial; Virucide; Hepatotropic; Antiinflammatory; Anti-HIV; Cytostatic; Antitubercular; Protozoacide. In tests in mice, subcutaneous injection of a composition containing 20 mu g Tat protein (as antigen), 5 mu g 4-amino-2-ethoxymethyl-alpha ,alpha -dimethyl-1H-imidazo-(4,5-c)-quinoline-1-ethanol(Ia)and 5 mu g ER804057 (IIa) gave an IgG1/IgG2a ratio 32 days later of 0.9, compared with 176.2 for Tat alone, 1.3 for Tat plus (Ia) and 3.5 for Tat plus (IIa), demonstrating that the combination of (Ia) and (IIa) orientated the immune response strongly towards the Th1 (rather than Th2) type. MECHANISM OF ACTION : Toll-like receptor 7 agonist; toll-like receptor 7 agonist; toll-like receptor 4 agonist.