Pyridinoylpiperidines as serotonin agonists and the use as medicaments for inhibition of neuronal protein extravasation, disorders due to dysfunction of the serotonin receptors and migraines

摘要

5-HT1F receptor agonists of formula I are described wherein: R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, heterocycle or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl or a group of formula II; R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C3 alkyl; and n is an integer from 1-6. Pharmaceutical compositions comprising the compounds are useful for activating 5-HT1F receptors, the inhibition of neuronal protein extravasation and for the treatment or prevention of migraines. Also described is a process for the production of the compounds.