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Vascularization enhanced intestinal submucosa tissue graft constructs prepared by seeding intestinal submucosa tissue in vitro with endothelial cells or endothelial cell precursors
Vascularization enhanced intestinal submucosa tissue graft constructs prepared by seeding intestinal submucosa tissue in vitro with endothelial cells or endothelial cell precursors
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机译:通过体外向内皮细胞或内皮细胞前体播种肠黏膜下组织制备血管化增强的肠黏膜下组织移植物
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摘要
An intestinal submucosa tissue graft construct for use in repairing diseased or damaged tissues in non-human animals is provided. The graft construct comprises vertebrate intestinal submucosa tissue, added endothelial cells, and at least one additional preselected, exogenous population of cells, which enhances initiation of the formation of vessel-like structures in the graft. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired. Methods for enhancing the vascularization in vivo of these intestinal submucosa tissues graft constructs and for preparing these grafts constructs are also provided.
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