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and genetically modified expanded hematopoietic stem cell human populations.
and genetically modified expanded hematopoietic stem cell human populations.
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机译:和转基因的扩增造血干细胞人群。
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摘要
A method for modifying a hematopoietic stem cell, comprising contacting a gene delivery vehicle comprising a polynucleotide sequence into contact with a population of cultured hematopoietic stem cells with fibronectin or RetroNectin¿ and in the presence of an amount of a mpl ligand and flt3 ligand (FL) which is sufficient to promote survival, expansion and / or transduction of hematopoietic stem cells, wherein: (i) the method is not a method for treatment of the human or animal body by surgery or therapy; and (ii) the method used human embryos for industrial or commercial purposes.
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