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New selenohydroxy acids and their derivatives applications in nutrition, cosmetics and pharmaceutics

机译:新硒酸羟基酸及其衍生物在营养,化妆品和药物中的应用

摘要

The purpose of this invention is: new selenohydroxy acid compounds and their derivatives; their process for the preparation; use of the new compounds as precursors of L(+)-selenomethionine and/or source of selenium in human or animal nutrition, in cosmetics and pharmaceutics; and nutritional, cosmetic and pharmaceutical compositions containing them. The new compounds that are the subject of this invention satisfy the general formula (I): in which n=0, 1 or 2, RSUB1/SUB=OH, OCORSUB3/SUB, OPOSUB3/SUBHSUB2/SUB, OPO(ORSUB4/SUB)(ORSUB5/SUB), or ORSUB6/SUB, RSUB2/SUB=OH, RSUB3/SUB, or NHRSUB7/SUB, RSUB3/SUB=particularly alkoxyl (CSUB1/SUB-CSUB26/SUB), ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6a and 6b, S-cysteinyl, or S-glutathionyl, carnitoyl, lipids, polyols, ORSUB4/SUB=ORSUB5/SUB=particularly alkoxyl (CSUB1/SUB-CSUB26/SUB), ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6a and 6b, S-cysteinyl, or S-glutathionyl, carnitoyl, lipids, polyols, ORSUB6/SUB=pyruvate, lactate, citrate, fumarate, maleate, myristate, palmitate, stearate, palmitoleate, oleate, linoleate, natural fatty acids, or 13-cis retinoate, RSUB7/SUB=H, alkyl, natural amino acids, or natural amines.
机译:本发明的目的是:新的硒代羟基酸化合物及其衍生物。他们的准备过程;在人或动物营养,化妆品和药物中,将新化合物用作L(+)-硒代蛋氨酸的前体和/或硒的来源;以及含有它们的营养,化妆品和药物组合物。作为本发明主题的新化合物满足通式(I):其中n = 0、1或2,R 1 = OH,OCOR 3 , OPO 3 H 2 ,OPO(OR 4 )(OR 5 )或OR 6 < / SUB>,R 2 = OH,R 3 或NHR 7 ,R 3 =尤其是烷氧基( C 1 -C 26 ),神经酰胺1,神经酰胺2,神经酰胺3,神经酰胺4,神经酰胺5,神经酰胺6a和6b,S-半胱氨酰基或S-谷胱甘肽肉碱,脂质,多元醇或OR 4 = OR 5 =尤其是烷氧基(C 1 -C 26 ),神经酰胺1,神经酰胺2,神经酰胺3,神经酰胺4,神经酰胺5,神经酰胺6a和6b,S-半胱氨酰基或S-谷胱甘肽,肉碱,脂质,多元醇或OR 6 =丙酮酸盐,乳酸盐,柠檬酸盐,富马酸酯,马来酸酯,肉豆蔻酸酯,棕榈酸酯,硬脂酸酯,棕榈糖酸酯,油酸酯,亚油酸酯,天然脂肪酸或13-顺式视黄酸酯,R 7 = H,烷基,天然氨基酸或天然胺。

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