TRICYCLIC COMPOUNDS AS INHIBITORS OF THE HYPOXIC SIGNALING PATHWAY

摘要

Tricyclic compounds that selectively inhibit HIF-la activity are disclosed. Methods also are disclosed for reducing HIF-1a activity, and for inhibiting angiogenesis, tumorigenesis and/or metastasis, in a subject. In some embodiments, the tricyclic compounds surprisingly inhibit HIF-la activity at non-cytotoxic concentrations, thereby avoiding drug side effects associated with significant cytotoxicity.