ORGANIC AMINE SALTS, AMINO ACIDS SALTS AND COMBRESTATIN A-4 PHOSPHATE AMINO ACID ESTER SALTS FOR MODULATING TUMOR OR METASTASIS PROLIFERATION AND BENIGN VASCULAR PROLIFERATIVE DISORDER GROWTH

摘要

FIELD: organic chemistry, medicine, oncology.;SUBSTANCE: invention relates to organic amine salts, amino acid salts and combrestatin A-4 phosphate amino acid ester salts. Invention describes compound of the general formula (I):; wherein one of substitute -OR¹ or -OR represents -O-QH⁺ and another one represents hydroxyl or -O-QH⁺; Q represents (A) optionally substituted aliphatic organic amine comprising at least one nitrogen atom that in common with proton forms quaternary ammonium cation QH⁺; (B) amino acid comprising at least two nitrogen atoms wherein one of nitrogen atoms in common with proton forms quaternary ammonium cation QH⁺; (C) amino acid comprising one or some nitrogen atoms wherein one of nitrogen atoms in common with proton forms quaternary ammonium cation QH⁺ and wherein, except for, all carboxyl groups of amino acids are in ester form. Also, invention describes pharmaceutical compositions used in modulation of tumor or metastasis proliferation and growth of benign vascular proliferative disorders, using compound of the formula (I) and a method for synthesis of compound of the formula (I). Invention provides preparing new combrestatin A-4 salts showing useful physicochemical properties that enhance solubility of combrestatin A-4.;EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.;27 cl, 13 dwg, 5 ex