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AZULENE DERIVATIVE AND SERUM CHOLESTEROL-REDUCING AGENT CONTAINING THE SAME AS ACTIVE SUBSTANCE
AZULENE DERIVATIVE AND SERUM CHOLESTEROL-REDUCING AGENT CONTAINING THE SAME AS ACTIVE SUBSTANCE
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机译:含氮祖灵衍生物和降低胆固醇含量的活性物质
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摘要
PROBLEM TO BE SOLVED: To provide a new azulene derivative having excellent serum cholesterol-reducing activities and useful as a serum cholesterol-reducing agent.;SOLUTION: The azulene derivative is a compound represented by general formula (I) [wherein, R1, R2 and R3 are the same or different, and each an azulene ring which may have a substituent or a benzene ring which may have a substituent (with the proviso that one of R1, R2 and R3 is always the azulene ring which may have a substituent); A is -(CH2)m-, -O-(CH2)n-, -CH=CH-(CH2)n-, -CH(OH)-(CH2)n- or -C(=O)-(CH2)n- (wherein, m is an integer of 1-5; and n is an integer of 1-4)] or a pharmaceutically acceptable salt thereof.;COPYRIGHT: (C)2008,JPO&INPIT
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机译:解决的问题:提供一种具有优异的降低血清胆固醇活性并可用作降低血清胆固醇的新的a唑衍生物。解决方案:z唑衍生物为通式(I)表示的化合物[其中,R <Sup > 1 Sup>,R 2 Sup>和R 3 Sup>相同或不同,各自可具有取代基的z环或苯环可具有取代基(前提是R 1 Sup>,R 2 Sup>和R 3 Sup>之一始终是可能具有取代基的z环); A是-(CH 2 Sub>) m Sub>-,-O-(CH 2 Sub>) n Sub>-,-CH = CH-(CH 2 Sub>) n Sub>-,-CH(OH)-(CH 2 Sub>) n Sub>-或-C(= O)-(CH 2 Sub>) n Sub>-(其中m是1-5的整数; n是1-4的整数) ]或其药学上可接受的盐。;版权所有:(C)2008,JPO&INPIT
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