Transgenic mice with the phenotype of major histocompatibility complex (MHC) in humans, applications and methods used for the experiment

摘要

Are those transgenic mice, on cells of the transgenic mice were isolated, the cells of the mouse and the mouse, the present invention, H-2 class II gene H-2 class I gene disrupted, destroyed, and includes the HLA class II transgene and a functional HLA class I transgene functional. In embodiments, lacks both class II molecules and H-2 class I molecules, the cells of transgenic mice or transgenic mice, HLA class II transgene and a functional HLA class I transgene functional contains. In embodiments, the cells of transgenic mice or transgenic mice, have a genotype of HLA-A2 ⁺ HLA-DR1 ⁺ β2m ° IAβ °. The present invention, it is also directed to a method of using a transgenic mouse according to the present invention. [Selection] Figure Figure 1