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Streptomyces avermitilis gene indicating the ratio of B2 avermectin: B1 avermectin
Streptomyces avermitilis gene indicating the ratio of B2 avermectin: B1 avermectin
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机译:阿维链霉菌基因,表明阿维菌素B2与阿维菌素B1之比
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摘要
The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
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