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摘要

PROBLEM TO BE SOLVED: To obtain the subject new cassette, derived from an internal ribosome entry site of a 5'-untranslated region of a chicken infectious bursal disease virus and useful for the production, etc., of a peptide using an animal vaccine or a virus. ;SOLUTION: This new multimolecule expression cassette is capable of expressing plural exogenotes and composed of the formula promoter-(exogenote)_m-(ires-exogenote)_n [the exogenote is an optional gene; ires is a DNA fragment complementary to an RNA capable of forming an internal ribosome entry site derived from a chicken infectious bursal disease virus (IBDV); (m) is 0 or 1; (n) is an integer value of ≥1] and is useful for the production of an animal polyvalent vaccine, the production, etc., of a peptide using a recombinant virus. The expression cassette is obtained by joining the internal ribosome entry site of the 5'-untranslated region of the IBDV to two or more exogenotes and a promoter.;COPYRIGHT: (C)1998,JPO