HEAT SHOCK RNA AND ITS USE IN ACTIVATION OF HEAT SHOCK TRANSCRIPTION FACTOR AND TREATMENT OF CANCER, INFLAMMATION, ISCHEMIA, NEURODEGENERATION, AGE-RELATED DISEASES, HIV INFECTION, DEAFNESS, AND RELATED DISORDERS

摘要

The present invention provides a novel RNA, designated herein as the “HSR1” (Heat Shock RNA), and its use together with translation elongation factor eEF1A in activation of heat shock transcription factor HSF. The invention further provides the use of HSR1 for generation of novel therapeutics for the treatment of cancer, inflammation, ischemia, neurodegeneration, age-related diseases, HIV infection, deafness, and related disorders.