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Prevention And Treatment Of Vascular Disease With Recombinant Adeno-Associated Virus Vectors Encoding Apolipoprotein A-I And Apolipoprotein A-I Milano
Prevention And Treatment Of Vascular Disease With Recombinant Adeno-Associated Virus Vectors Encoding Apolipoprotein A-I And Apolipoprotein A-I Milano
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机译:编码载脂蛋白A-I和载脂蛋白A-I Milano的重组腺相关病毒载体预防和治疗血管疾病
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摘要
Described herein is a gene therapeutic approach to the prevention and treatment of vascular disease and coronary heart disease; in particular, atherosclerosis. The inventive methods may be used in the prevention and treatment of atherosclerosis, as well as any disease or physiological condition in which atherosclerosis plays a role. The inventive methods involve the gene delivery of ApoA-I or ApoA-IMilano. This may be accomplished by the use of rAAV technology. rAAV virions may be delivered to a mammalian subject by various methodologies, including transplantation of transduced bone marrow cells, direct intramuscular injection, intravenous or portal vein injection or stent delivery.
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