Holt's O(log N) method to search a massively poly-clonal collection of hybridomas to detect, select and isolate target-antigen-specific high-affinity monoclonal-antibody-generating hybridomas for the rapid development and manufacture of highly specific and effectively targeted monoclonal antibodies

摘要

This invention is an O(Log N) technique that searches a massively poly-clonal collection of hybridomas (or other monoclonal antibody generators) to detect, select and isolate target-antigen-specific high-affinity monoclonal-antibody-generating hybridomas (or other monoclonal antibody generators) for the rapid development and manufacture of highly specific and effectively targeted monoclonal antibodies. It expedites the manufacture of monoclonal antibodies targeted at a specific antigen or collection of antigens—making the generation of “poly-monoclonal” antibody “cocktails” more practical and efficient.