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Controlled drug delivery system using the conjugation of drug to biodegradable polyester
Controlled drug delivery system using the conjugation of drug to biodegradable polyester
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机译:使用药物与可生物降解的聚酯结合的可控药物输送系统
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摘要
The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.
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